ASSA14-13-01 Cigarette smoking-induced LDL dysfunction is partially reversible after smoking cessation
Autor: | Lianfeng Chen, Wei Wu, C Feng, Xu Yan, Yan Zhang |
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Rok vydání: | 2014 |
Předmět: |
medicine.medical_specialty
Tobacco use biology business.industry medicine.medical_treatment medicine.disease biology.organism_classification Surgery Coronary artery disease Endocrinology Cigarette smoking Enos Internal medicine medicine Smoking cessation Risk factor Endothelial dysfunction Cardiology and Cardiovascular Medicine business Lipoprotein |
Zdroj: | Heart. 101:A40.2-A41 |
ISSN: | 1468-201X 1355-6037 |
Popis: | Background Increased level of low-density lipoprotein (LDL) is a well-established risk factor of atherogenesis. Cigarette smoking leads to endothelial dysfunction, an early event of atherogenesis. Objective To investigate the effect of smoking and smoking cessation on the atherogenesis of LDL and possible differences of this effect between long-term smokers with and without CAD Methods Human umbilical vascular endothelial cells (HUVECs) were treated with 50 and 100 μg/ml LDL isolated from long-term smokers with or without coronary artery disease (CAD), before and after smoking cessation. Functional changes of HUVECs were evaluated by measuring oxidative markers (MDA, LOX-1), NO, eNOS and inflammatory markers (TNF-α, IL-1β, MMP-9). Results PlasmaLDL levels of long-term (>10 years) smokers were significantly higher than that of non-smokers (p Conclusion Long-term cigarettes smoking had significant pro-oxidative and pro-inflammatory effects on LDLparticles which could lead to endothelial dysfunction. The detrimental effects of smoking on LDL could be partially reversed by 90days’ smoking cessation. |
Databáze: | OpenAIRE |
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