Systematized Epidermal Nevus with Epidermolytic Hyperkeratosis Improving with Topical Calcipotriol/Betametasone Dipropionate Combination Ointment
| Autor: | Joyce Siong See Lee, Wei-Sheng Chong, Mark Jean Aan Koh |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Pathology Systematized epidermal nevus integumentary system medicine.diagnostic_test business.industry Hyperkeratosis Betamethasone dipropionate Dermatology medicine.disease Keratin 1 Epidermolytic hyperkeratosis chemistry.chemical_compound chemistry Pediatrics Perinatology and Child Health Skin biopsy Keratin medicine skin and connective tissue diseases business Calcipotriol medicine.drug |
| Zdroj: | Pediatric Dermatology. 30:370-373 |
| ISSN: | 0736-8046 |
| Popis: | We present the case of a 5-year-old boy who presented with systematized epidermal nevus with evidence of epidermolytic hyperkerato- sis on skin biopsy. He was otherwise well, with normal growth and development and no evidence of other organ system involvement. He had experienced only mild improvement with potent topical corticosteroids. He reported more-marked improvement after 2 months of topical calcipotri- ol ⁄betamethasone dipropionate combination ointment once a day to the lesions. Extensive epidermal nevi can lead to severe cosmetic disfigurement. We recommend a trial of topical calcipotriol ⁄betamethasone dipropionate ointment for patients with extensive epidermal nevus not amenable to surgical treatment. Epidermal nevi are relatively common, benign epi- dermal proliferations usually present at birth or appearing in early childhood and often found along the lines of Blaschko. Although usually occurring as a single lesion, multiple lesions may be present in some patients. Systematized epidermal nevus has been used to describe extensive lesions occurring bilaterally. Histopathologi- cally, some epidermal nevi may reveal features of epi- dermolytic hyperkeratosis, indicating a mosaic mutation in keratin 1 or keratin 10 genes. Epidermal nevi are dif- ficult to treat, especially in patients with widespread involvement. We describe a case of a young boy with systematized epidermal nevus with histologic features of epidermolytic hyperkeratosis, improving with topical calcipotriol ⁄ betamethasone dipropionate combination ointment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text