| Autor: |
Pranav Sharma, Mariela Pow-Sang, Julio M. Pow-Sang |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Penile Cancer ISBN: 9781493966776 |
| DOI: |
10.1007/978-1-4939-6679-0_2 |
| Popis: |
Resection of high-risk primary penile tumors with either partial or total penectomy can often lead to esthetically disfiguring outcomes as well as poor functional quality with regard to the ability for intercourse. Pretreatment diagnostic tools are necessary to better define those patients in whom penile-sparing approaches may achieve equivalent oncological outcomes without compromising penile length or functional ability. Additionally, due to the morbidity associated with inguinal and pelvic lymph node (LN) dissection, diagnostic tools that can accurately identify lymphatic metastases from penile carcinoma are necessary to optimize diagnosis and treatment, especially since the extent of LN involvement is the most relevant prognostic factor in penile cancer patients. These novel strategies may help avoid the unnecessary morbidity of inguinal and/or pelvic lymphadenectomy in patients that may not benefit from aggressive surgical intervention and better cater treatment for those in which it is clinically indicated. These emerging diagnostic tools may consist of imaging-based modalities, molecular-based drug delivery systems, and tissue-based biomarkers. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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