Copper(i)/DM-SEGPHOS-catalyzed enantio- and diastereoselective conjugate boration to α-alkylidene-γ-lactams

Autor:	Kyungsoo Oh, Jimil George, Hun Young Kim
Rok vydání:	2020
Předmět:	chemistry.chemical_compound SEGPHOS Chemistry Stereochemistry Organic Chemistry Enantioselective synthesis chemistry.chemical_element Stereoselectivity Reactivity (chemistry) Copper Catalysis Conjugate
Zdroj:	Organic Chemistry Frontiers. 7:709-714
ISSN:	2052-4129
DOI:	10.1039/c9qo01504c
Popis:	A combination of CuCl and DM-SEGPHOS catalyst system has allowed the development of highly enantioselective and diastereoselective conjugate addition of bis(pinacolato)diboron to α-alkylidene-γ-lactams. The key structural feature of conjugate acceptors, α-alkylidene-γ-lactams, was identified as the carbamate group such as N-Boc and N-Cbz, where the typical low reactivity and stereoselectivity issues associated with α,β-unsaturated lactams as conjugate acceptors were resolved.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a346645a01976b31df28f1087896a22d https://doi.org/10.1039/c9qo01504c Zobrazit plný text záznamu