Human leukocyte antigens (HLA) association with myasthenia gravis (MG) and its myasthenia manifestations in Algerian patients
| Autor: | Meçabih Fethi, Touil-Boukoffa Chafia, Bouchtout Mohamed Nadji, Raache Rachida, Attal Nabila, Attal Elias, Boukadir Chahrazad, Daoudi Smail, Mihoubi Esma |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Autoimmune disease biology business.industry Human leukocyte antigen medicine.disease Myasthenia gravis law.invention HLA-A 03 medical and health sciences 030104 developmental biology 0302 clinical medicine law 030220 oncology & carcinogenesis Immunology Genetics medicine biology.protein Antibody Allele business Genetics (clinical) Polymerase chain reaction Acetylcholine receptor |
| Zdroj: | Meta Gene. 29:100937 |
| ISSN: | 2214-5400 |
| DOI: | 10.1016/j.mgene.2021.100937 |
| Popis: | Background Myasthenia gravis (MG) is an autoimmune disease with a well-established involvement of genetic factors. Aim this study was to assess the human leukocyte antigens (HLA) genes association with myasthenia gravis and its myasthenic manifestations. Methods We performed a case-control study where twenty eight patients and one hundred and nine healthy subjects were included. A subgroup of generalized and acetylcholine receptor antibodies positive myasthenia gravis was examined for myasthenic manifestations associations. HLA genotyping was performed by polymerase chain reaction- sequence specific oligonucleotide (PCR-SSO) method. Results On one hand, HLA A*30 and DRB1*04 alleles were more frequent among patients with myasthenia gravis whereas A*02 and B*49 were less frequent (p Conclusion Our results suggest the association of various HLA alleles with myasthenia gravis and some of its myasthenic manifestations. However, further studies are required support these findings and clarify the underlying mechanisms. |
| Databáze: | OpenAIRE |
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