Salmonella Vaccines: Conduits for Protective Antigens

Autor:	Roy Curtiss, Josephine E. Clark-Curtiss
Rok vydání:	2018
Předmět:	0301 basic medicine medicine.drug_class Immunology Antibiotics Salmonella vaccine Drug resistance Biology 03 medical and health sciences 030104 developmental biology Immune system Antigen Immunity Infectious disease (medical specialty) medicine Immunology and Allergy Pathogen
Zdroj:	The Journal of Immunology. 200:39-48
ISSN:	1550-6606 0022-1767
Popis:	Vaccines afford a better and more cost-effective approach to combatting infectious diseases than continued reliance on antibiotics or antiviral or antiparasite drugs in the current era of increasing incidences of diseases caused by drug-resistant pathogens. Recombinant attenuated Salmonella vaccines (RASVs) have been significantly improved to exhibit the same or better attributes than wild-type parental strains to colonize internal lymphoid tissues and persist there to serve as factories to continuously synthesize and deliver rAgs. Encoded by codon-optimized pathogen genes, Ags are selected to induce protective immunity to infection by that pathogen. After immunization through a mucosal surface, the RASV attributes maximize their abilities to elicit mucosal and systemic Ab responses and cell-mediated immune responses. This article summarizes many of the numerous innovative technologies and discoveries that have resulted in RASV platforms that will enable development of safe efficacious RASVs to protect animals and humans against a diversity of infectious disease agents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a33c38cecaae54a8ed1934b80ee4e4f9 https://doi.org/10.4049/jimmunol.1600608 Zobrazit plný text záznamu