The Nitration of 8-Methylquinoxalines in Mixed Acid

Autor:	Wolfgang Marterer, and Jacques Wiss, Mahavir Prashad, Walter Prikoszovich
Rok vydání:	2003
Předmět:	chemistry.chemical_compound Hydrolysis chemistry Nitration Organic Chemistry Halogen Organic chemistry Halogenation Physical and Theoretical Chemistry
Zdroj:	Organic Process Research & Development. 7:318-323
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op0340255
Popis:	8-Methylquinoxalines are nitrated surprisingly efficiently at C-5 following a simple nitration protocol with mixed acid at 40−50 °C. The implications of halogen functionalisation at C-6 and modification of the mixed acid conditions on the relative rates of conversion and process safety are discussed. Competing side reactions for 6-halo-8-methylquinoxalines involve hydrolysis at C-6 and halogenation at C-7 or C-5.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a33baf0212aca4205f99e56ef3f5c728 https://doi.org/10.1021/op0340255 Zobrazit plný text záznamu