Characterization of the morphology and hydrophilicity of chitosan/caffeic acid hybrid scaffolds
| Autor: | Hsing-Ya Li, Yu-Ru Su, An-Chong Chao, Zu-Chian Chiang |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Scaffold
Materials science Morphology (linguistics) Polymers and Plastics Scanning electron microscope Organic Chemistry food and beverages Potassium persulfate Grafting Chitosan chemistry.chemical_compound Differential scanning calorimetry chemistry Chemical engineering Materials Chemistry Caffeic acid Composite material |
| Zdroj: | Journal of Polymer Research. 18:2205-2212 |
| ISSN: | 1572-8935 1022-9760 |
| DOI: | 10.1007/s10965-011-9631-5 |
| Popis: | The morphology and affinity of a scaffold influence the attachment of cells to its surfaces. In this study, the morphology and hydrophilicity of chitosan/caffeic acid hybrid scaffolds were investigated. Grafting caffeic acid onto chitosan hybrid scaffolds by using high levels of potassium persulfate produced scaffolds with looser morphology and higher porosity, as indicated by scanning electron microscopy (SEM) and porosity analysis. SEM analysis showed that the prepared scaffolds had a macroporous morphology with interconnected pores. Differential scanning calorimetry (DSC) revealed that the scaffolds’ hydrophilicity decreased after caffeic acid grafting. The scaffolds were cultured with human osteosarcoma UMR-106 cells, but SEM analysis showed that cell attachment was poor. However, calcification of the scaffolds promoted the attachment of UMR-106 cells onto the scaffold. This study shows that calcified chitosan/caffeic acid hybrid scaffolds could be suitable for use in hard-tissue engineering. |
| Databáze: | OpenAIRE |
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