| Autor: |
N. Capraosa, V. Zenger, J. Whitehouse, Robert F. Vogt, T. A. Fleisher, J. Muller, C. I. Amos, G. C. Washington, P. Bertin, Gerald E. Marti, G. B. Faguet, P. Carter, P. Branham, Carleton C. Stewart |
| Rok vydání: |
1992 |
| Předmět: |
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| Zdroj: |
Current Topics in Microbiology and Immunology ISBN: 9783642776359 |
| DOI: |
10.1007/978-3-642-77633-5_38 |
| Popis: |
B-chronic lymphocytic leukemia (B-CLL) is a disease manifested by the proliferation and accumulation of a clone(s) of medium-sized lymphocytes with mature-appearing chromatin and a characteristic surface immunophenotype. Monoclonality is usually evidenced by the presence of a single heavy and light chain immunoglobulin and or a rearranged Ig gene(s). The surface fluorescence intensity (FI) of membrane Ig is markedly diminished and ineffective rearrangements are common. Typically patients fifty years of age or older present with a stable, asymtomatic blood and marrow monoclonal B lymphocytosis. Blood lymphocytes may show considerable cytological or morphological variation between patients and within patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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