Angiogenesis in endometrial hyperplasia and stage I endometrial carcinoma
| Autor: | Christine C. Hansen, David M. Sherer, Fabio Ghezzi, Ovadia Abulafia, William E. Triest |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Pathology
medicine.medical_specialty Hysterectomy Epithelioma business.industry medicine.medical_treatment Obstetrics and Gynecology Hyperplasia medicine.disease Endometrium Endometrial hyperplasia Neovascularization medicine.anatomical_structure Carcinoma medicine medicine.symptom business Microvessel |
| Zdroj: | Obstetrics & Gynecology. 86:479-485 |
| ISSN: | 0029-7844 |
| DOI: | 10.1016/s0029-7844(95)80001-8 |
| Popis: | Objective: To evaluate angiogenesis in endometrial hyperplasia and stage I endometrial carcinoma, and to investigate the relationship between angiogenesis and tumor grade and depth of invasion. Methods: Three groups of patients were analyzed: control patients who underwent hysterectomy for benign conditions ( n = 19), patients with endometrial hyperplasia ( n = 24), and patients with stage I endometrial carcinoma ( n = 34). All hysterectomy specimens were stained immunohistochemically for factor VIII-related antigen as a sensitive and specific marker for vascular endothelium. Areas close to the deepest myometrial invasion or those with the highest grade of endometrial hyperplasia and the highest angiogenic intensity were selected. Three fields (× 400) were selected for each slide, and the mean microvessel count was calculated. Statistical analysis included Mann-Whitney U test ir Kruskal-Wallis analysis of variance and Dunn post hoc procedure. P Results: A significant difference was found between the microvessel count of controls versus the group with complex endometrial hyperplasia (median 21, range 16–80, versus median 38, range 20–130; P P P P = .5). In cases of stage I endometrial carcinoma, a higher number of microvessels was noted in specimens with myometrial invasion than in those without myometrial invasion (median 44, range 19–119, versus median 83, range 19–189; P P Conclusion: Complex endometrial hyperplasia and endometrial carcinoma are angiogenic. Furthermore, in stage I endometrial carcinoma, greater depth of invasion and higher tumor grade are directly correlated with angiogenic intensity. |
| Databáze: | OpenAIRE |
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