Bilateral volume reduction in posterior hippocampus in psychosis of epilepsy
| Autor: | Dennis Velakoulis, Terry O'Brien, Patrick Kwan, Sophia J. Adams, Simon Vogrin, Jerome Joseph Maller, James Allebone, Sarah J. Wilson, Graeme D. Jackson, Saul A. Mullen, Richard A A Kanaan, David N. Vaughan, Samuel F. Berkovic, Mark J. Cook, Wendyl D'Souza, Alan Connelly |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Psychosis business.industry Hippocampus Hippocampal formation medicine.disease Lobe 030227 psychiatry Temporal lobe 03 medical and health sciences Psychiatry and Mental health Epilepsy 0302 clinical medicine medicine.anatomical_structure Schizophrenia Internal medicine Cardiology Medicine Surgery Ictal Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurology, Neurosurgery & Psychiatry. 90:688-694 |
| ISSN: | 1468-330X 0022-3050 |
| DOI: | 10.1136/jnnp-2018-319396 |
| Popis: | ObjectivePsychosis of epilepsy (POE) occurs more frequently in temporal lobe epilepsy, raising the question as to whether abnormalities of the hippocampus are aetiologically important. Despite decades of investigation, it is unclear whether hippocampal volume is reduced in POE, perhaps due to small sample sizes and methodological limitations of past research.MethodsIn this study, we examined the volume of the total hippocampus, and the hippocampal head, body and tail, in a large cohort of patients with POE and patients with epilepsy without psychosis (EC). One hundred adults participated: 50 with POE and 50 EC. Total and subregional hippocampal volumes were manually traced and compared between (1) POE and EC; (2) POE with temporal lobe epilepsy, extratemporal lobe epilepsy and generalised epilepsy; and (3) patients with POE with postictal psychosis (PIP) and interictal psychosis (IP).ResultsCompared with EC the POE group had smaller total left hippocampus volume (13.5% decrease, pConclusionPosterior hippocampal volumes are bilaterally reduced in POE. Volume loss was observed on a posteroanterior gradient, with severe decreases in the tail and moderate volume decreases in the body, with no difference in the hippocampal head. Posterior hippocampal atrophy is evident to a similar degree in PIP and IP. Our findings converge with those reported for the paradigmatic psychotic disorder, schizophrenia, and suggest that posterior hippocampal atrophy may serve as a biomarker of the risk for psychosis, including in patients with epilepsy. |
| Databáze: | OpenAIRE |
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