Urine Quantification Following Furosemide for Severe Acute Kidney Injury Prediction in Critically Ill Children
| Autor: | Jamie Penk, Eric L. Wald, Katja M. Gist, John T. Brinton, Stuart L. Goldstein, Kelli A. Krallman, Tennille N. Webb, Laura Kitzmiller, Danielle E. Soranno, Rajit K. Basu |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment 030232 urology & nephrology 030204 cardiovascular system & hematology urologic and male genital diseases Critical Care and Intensive Care Medicine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Urine flow rate medicine Mechanical ventilation Creatinine business.industry Acute kidney injury Furosemide Retrospective cohort study medicine.disease female genital diseases and pregnancy complications Cardiac surgery chemistry Anesthesia Pediatrics Perinatology and Child Health business medicine.drug Kidney disease |
| Zdroj: | Journal of Pediatric Intensive Care. |
| ISSN: | 2146-4626 2146-4618 |
| DOI: | 10.1055/s-0041-1732447 |
| Popis: | A standardized, quantified assessment of furosemide responsiveness predicts acute kidney injury (AKI) in children after cardiac surgery and AKI progression in critically ill adults. The purpose of this study was to determine if response to furosemide is predictive of severe AKI in critically ill children outside of cardiac surgery. We performed a multicenter retrospective study of critically ill children. Quantification of furosemide response was based on urine flow rate (normalized for weight) measurement 0 to 6 hours after the dose. The primary outcome was presence of creatinine defined severe AKI (Kidney Disease Improving Global Outcomes stage 2 or greater) within 7 days of furosemide administration. Secondary outcomes included mortality, duration of mechanical ventilation and length of stay. A total of 110 patients were analyzed. Severe AKI occurred in 20% (n = 22). Both 2- and 6-hour urine flow rate were significantly lower in those with severe AKI compared with no AKI (p = 0.002 and p |
| Databáze: | OpenAIRE |
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