Immunohistochemical localization of cyclooxygenase and prostaglandin I2 synthase in human female reproductive organs
| Autor: | Yoshinori Otsuki, O. Misaki, Hiromichi Kubo, Shogo Tsubokura, Yukihiro Akao, Osamu Sugimoto, Minoru Ueki |
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| Rok vydání: | 1995 |
| Předmět: |
Cell type
medicine.medical_specialty biology Uterus Prostaglandin General Medicine Pathology and Forensic Medicine Andrology chemistry.chemical_compound medicine.anatomical_structure Endocrinology chemistry Cytoplasm Internal medicine biology.protein medicine Immunohistochemistry Cyclooxygenase Anatomy Molecular Biology Fallopian tube Hormone |
| Zdroj: | Medical Electron Microscopy. 28:118-125 |
| ISSN: | 1860-1499 0918-4287 |
| DOI: | 10.1007/bf02348029 |
| Popis: | The localization of cyclooxygenase and prostaglandin I2 synthase in human female reproductive organs was examined by immunohistochemistry. Cyclooxygenase was localized in the cytoplasm of various cell types. The extent of cyclooxygenase expression in endometrial epithelial cells varied with the menstrual cycle, showing a peak at the secretory phase. Cyclooxygenase was also detected in the secretory cells, but not in the ciliated cells, of the fallopian tubes. Prostaglandin I2 synthase was detected in the cytoplasm of myometrial cells throughout the menstrual cycle and during pregnancy. The results suggest that cyclooxygenase expression in endometrial epithelial cells may be regulated by ovarian hormones, and that the localization of cyclooxygenase in secretory cells—but not ciliated cells—in the fallopian tube may reflect the different functions of these two cell types. |
| Databáze: | OpenAIRE |
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