Electrochemical microsensor system for cancer research on photodynamic therapy in vitro

Autor:	Julia Marzioch, Jochen Kieninger, Gerald Urban, Q. Peng, Erik O. Pettersen, Joe Alexander Sandvik
Rok vydání:	2016
Předmět:	History Materials science medicine.medical_treatment Laser source fungi Nanotechnology Photodynamic therapy Electrochemistry In vitro Computer Science Applications Education Redox Activity Photon emission medicine Photosensitizer Biomedical engineering
Zdroj:	Journal of Physics: Conference Series. 757:012002
ISSN:	1742-6596 1742-6588
Popis:	An electrochemical microsensor system to investigate photodynamic therapy of cancer cells in vitro was developed and applied to monitor the cellular respiration during and after photodynamic therapy. The redox activity and therefore influence of the photodynamic drug on the sensor performance was investigated by electrochemical characterization. It was shown, that appropriate operation conditions avoid cross-sensitivity of the sensors to the drug itself. The presented system features a cell culture chamber equipped with microsensors and a laser source to photodynamically treat the cells while simultaneous monitoring of metabolic parameter in situ. Additionally, the optical setup allows to read back fluorescence signals from the photosensitizer itself or other marker molecules parallel to the microsensor readings.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a3148034d5d5dd6ae90406805b00c33a https://doi.org/10.1088/1742-6596/757/1/012002 Zobrazit plný text záznamu