Expression of Vascular Endothelial Growth Factor and Placenta Growth Factor in Human Placenta1
| Autor: | Piia Vuorela, Vladimir Joukov, Kari Alitalo, Erja Halmesmäki, Erika Hatva, M. G. Persico, Athina Lymboussaki, Arja Kaipainen |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Biology Andrology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Placenta medicine reproductive and urinary physiology 030304 developmental biology 0303 health sciences 030219 obstetrics & reproductive medicine Growth factor Decidua Cell Biology General Medicine Endothelial stem cell Vascular endothelial growth factor B Vascular endothelial growth factor Vascular endothelial growth factor A Endocrinology medicine.anatomical_structure Reproductive Medicine PIGF chemistry embryonic structures |
| Zdroj: | Biology of Reproduction. 56:489-494 |
| ISSN: | 1529-7268 0006-3363 |
| DOI: | 10.1095/biolreprod56.2.489 |
| Popis: | Normal development and function of the placenta requires invasion of the maternal decidua by trophoblasts, followed by abundant and organized vascular growth. Little is known of the significance and function of the vascular endothelial growth factor (VEGF) family, which includes VEGF, VEGF-B, and VEGF-C, and of placenta growth factor (PIGF) in these processes. In this study we have analyzed the expression of VEGF and PIGF mRNAs and their protein products in placental tissue obtained from noncomplicated pregnancies. Expression of VEGF and PIGF mRNA was observed by in situ hybridization in the chorionic mesenchyme and villous trophoblasts, respectively. Immunostaining localized the VEGF and PIGF proteins in the vascular endothelium, which was defined by staining for von Willebrand factor and for the Tie receptor tyrosine kinase, an early endothelial cell marker. VEGF-B and VEGF-C mRNAs were strongly expressed in human placenta as evidenced by Northern blot analysis. These data imply that VEGF and PIGF are produced by different cells but that both target the endothelial cells of normal human term placenta. |
| Databáze: | OpenAIRE |
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