| Popis: |
We evaluated the applicability and effectiveness of support with a combination of an extra-aortic balloon (EAB) and a ventricular assist cup (VAC), using an acute heart failure model. Under general anesthesia, ten adult dogs were used. Through median sternotomy, an EAB was placed around the ascending aorta and a VAC in the pericardial cavity. After heart failure was induced by the administration of propranolol, on-off tests of devices were performed as follows: EAB only; VAC only; and both devices in operation. Regional blood flows (RBFs) in both ventricles and in the liver, kidney, and brain were measured using a colored microsphere technique. Aortic flow and cardiac output were also measured. In the heart failure model, aortic flow and cardiac output decreased to 65% and 66% of the control value, respectively. With assistance by the EAB only, RBFs in both ventricle and brain increased significantly. With only the VAC on, RBFs in all but the left ventricle significantly increased. With both the EAB and the VAC on, all five RBFs significantly increased. These results suggest that the combination of EAB and VAC is applicable and effective, and would be a very promising implantable device for chronic heart failure. |
