Neuronspezifische Enolase als Tumormarker beim kleinzelligen Bronchuskarzinom

Autor:	Elisabeth Müller-Holzner, M. Herold, Georg M. Salzer, Heinz Huber, L. Ch. Müller, R. W. Gasser
Rok vydání:	2008
Předmět:	endocrine system Tumour regression Pathology medicine.medical_specialty Extensive Disease business.industry Microgram Cell General Medicine Positive correlation Tumour stage Serum NSE level medicine.anatomical_structure nervous system Bronchial carcinoma medicine business
Zdroj:	DMW - Deutsche Medizinische Wochenschrift. 113:1708-1713
ISSN:	1439-4413 0012-0472
Popis:	Neurone specific enolase (NSE) was measured in serum from 54 patients with untreated bronchial carcinoma. Serum NSE was elevated (greater than 12.5 micrograms/l) in 24 of 31 patients (77.4%) with small cell bronchial carcinoma, but in only 4 of 23 (17.4%) with non-small cell bronchial carcinoma. The median serum NSE level was significantly higher for small cell bronchial carcinoma than for the other forms (23.6 micrograms/l vs. 8.0 micrograms/l; P less than 0.001). NSE levels had a positive correlation to the tumour stage for the small cell tumour: median of 16.5 micrograms/l in "limited disease" (16 cases) and 43.2 micrograms/l in "extensive disease" (15 cases). Serum NSE levels seem to be suitable markers for documenting the course of small cell bronchial carcinoma: 15 patients with tumour regression or remission had normal NSE values while elevated levels were found in 7 of 8 patients with progression. NSE was demonstrated immunohistologically both in small cell and non-small cell bronchial carcinoma tissue, but high NSE levels were predominantly present in small cell carcinomas.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a30e4cd91eb627501a58872e5799822a https://doi.org/10.1055/s-2008-1067876 Zobrazit plný text záznamu