Multiple Sclerosis Susceptibility. Population and Twin Study of Polymorphisms in the T-Cell Receptor β and γ Genes Region
| Autor: | Laurence Briant, Philippe Avoustin, John Clayton, Michael McDermott, Michel Clanet, Anne Cambon-thomsen, null French Group on Multiple Sclerosis |
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| Rok vydání: | 1993 |
| Předmět: |
Genetics
education.field_of_study biology Multiple sclerosis Immunology T-cell receptor Population Immunogenetics medicine.disease Major histocompatibility complex T-Cell Receptor Gene medicine biology.protein Immunology and Allergy Gene polymorphism Restriction fragment length polymorphism education |
| Zdroj: | Autoimmunity. 15:67-73 |
| ISSN: | 1607-842X 0891-6934 |
| DOI: | 10.3109/08916939309004841 |
| Popis: | Multiple sclerosis (MS) is a demyelinating auto-immune disease of the central nervous system with a suspected genetic component.Previous publications have demonstrated that MS susceptibility is influenced by Major Histocompatibility Complex (MHC) genes and recent studies have focused on additional susceptibility genes. The accumulation of activated T-cells in demyelinating MS lesions, the possible auto-immune mechanism of this disease and the functional relationship between MHC and T cell receptor (TCR) molecules support the hypothesis that TCR genes are good candidates to influence MS development. Published results in this domain are conflicting and still a matter of controversy.In the present study we analysed the influence of Vβ, Cβ, PλG3 and Vγ gene polymorphisms defined by Restriction Fragments Length Polymorphism (RFLP) on 48 pairs of monozygotic and dizygotic twins with at least one of each pair affected, and also in 63 unrelated MS patients for Vγ gene polymorphism. These results have been compare... |
| Databáze: | OpenAIRE |
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