OC-088 CAN PROCOLLAGEN I AND PROCOLLAGEN III SERVE AS PREDICTIVE BIOMARKERS FOR INCISIONAL HERNIA RECURRENCE?
| Autor: | J Pilkington, F Wilkinson, J Pritchett, C Fullwood, A J Sheen |
|---|---|
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | British Journal of Surgery. 109 |
| ISSN: | 1365-2168 0007-1323 |
| DOI: | 10.1093/bjs/znac308.098 |
| Popis: | Background The aim of this study was to determine the temporal evolution of extracellular matrix (ECM) remodelling and collagen biomarkers and their influence on incisional hernia recurrence after the IPOM plus repair. Methods A sub-cohort of patients (n=25) undergoing laparoscopic incisional hernia repair within the TACKoMesh randomised controlled trial were bled at serial timepoints up to 1-year following surgery. Serum/plasma concentration of biomarkers (Procollagen I, Procollagen III, Fibronectin, TGF-beta, MMP-2, MMP-9, TIMP-1, and TIMP-2) were quantified using ELISA and Luminex multiplex techniques. Data were described and compared between groups that developed and remained free from recurrence using R statistical software. Results Procollagen I was reduced relative to baseline on post-op Day 1 but increased at Days 6 and 30 (p Fibronectin was reduced at Day 1 and 6 (p Conclusion In patients that developed incisional hernia recurrence, low levels of Procollagen I and high levels of Procollagen III were detected. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|