Depletion of O6-methylguanine-DNA methyltransferase activity and potentiation of 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3 (2-chloroethyl)-3-nitro-sourea antitumor effect by streptozotocin

Autor:	Yue-Neng Chen, Yang-Pei Zhang, Jian-Min Chen, Jianli Sui
Rok vydání:	1993
Předmět:	Cancer Research Methyltransferase Long-term potentiation Drug resistance Pharmacology Biology Streptozotocin In vitro chemistry.chemical_compound medicine.anatomical_structure Oncology chemistry medicine Nitro neoplasms Sensitization DNA medicine.drug
Zdroj:	Chinese Journal of Cancer Research. 5:48-52
ISSN:	1000-9604
DOI:	10.1007/bf02997493
Popis:	O6-methylguanine-DNA Methyltransferase (MGMT) can specifically repair the DNA demage induced by chloroethylnitrosoureas (CENU) such as 1-(4-amino-2-mcthja-pyrimidinyl) methyl- 3- (2- chloroethyl)- 3-nitrosourea (ACNU), constituting the molecular basis of tumor cell resistance to CENU. The present study demonstrated that sensitization of resistant tumor cells to ACNU could be achieved by streptozotocin (STZ) treatment which could deplete MGMT activityin vitro andin vivo. It suggested that depletion of the molecular basis of tumor cell resistance to chemotherapeutic agents might be a practicable way to improve the effectiveness of tumor chemotherapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a30341a83940992e129b8aaae857809a https://doi.org/10.1007/bf02997493 Zobrazit plný text záznamu Full text from SpringerLink