Synthesis of primary amides by aminocarbonylation of aryl/hetero halides using non-gaseous NH3 and CO sources

Autor:	Poongavanam Baburajan, Mansur Ahmed, Awale Suresh
Rok vydání:	2015
Předmět:	chemistry.chemical_compound Primary (chemistry) chemistry Aryl Amide Organic Chemistry Drug Discovery Halide Biochemistry Combinatorial chemistry Gaseous ammonia Carbon monoxide
Zdroj:	Tetrahedron Letters. 56:4864-4867
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2015.06.054
Popis:	A practically simple method for the synthesis of primary amides via the palladium-catalysed aminocarbonylation of aromatic halides by using solid sources of gaseous ammonia and carbon monoxide is described. The system tolerated a wide variety of hindered and functionalized aryl/hetero halides and afforded good to excellent yields (69–94%) of the amide. Pharmacologically active Exalamide and Pyrazinecarboxamide were synthesised in high yields to demonstrate the effectiveness of this method.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a2fd287d3ab56df52c50b7b60c918ab1 https://doi.org/10.1016/j.tetlet.2015.06.054 Zobrazit plný text záznamu Full Text from ScienceDirect