Xylopins A–F, six rare guaiane dimers with three different connecting modes from Xylopia vielana
| Autor: | Shi-Kai Yan, Xisong Ke, Rong Yan, Yuanqiang Guo, Huang Piao, Weidong Zhang, Yang-Guo Xie, Xianglong Zhong, Hui-Zi Jin, Ishaq Muhammad |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.diagnostic_test
Stereochemistry General Chemical Engineering Wnt signaling pathway 02 engineering and technology General Chemistry Cell cycle 010402 general chemistry 021001 nanoscience & nanotechnology Sesquiterpene 01 natural sciences 0104 chemical sciences Flow cytometry chemistry.chemical_compound Western blot chemistry medicine Signal transduction 0210 nano-technology Two-dimensional nuclear magnetic resonance spectroscopy Xylopia vielana |
| Zdroj: | RSC Advances. 9:9235-9242 |
| ISSN: | 2046-2069 |
| DOI: | 10.1039/c9ra00347a |
| Popis: | Six rare guaiane-type sesquiterpene dimers xylopins A–F, having three different connecting modes through two direct C–C bonds, were isolated from the roots of Xylopia vielana. Their absolute configurations were established by NOESY analysis, Cu Kα X-ray crystallography, and experimental and calculated electronic circular dichroism spectra. Flow cytometry demonstrated the fact that compound 6 arrested the cell cycle at G2 phase and concentration-dependently induced apoptosis of DU145 cells. Furthermore, the EPT2-TGC cell model, zebrafish study and western blot analysis illustrated compound 6 could induce apoptosis by efficiently inhibiting the Wnt/β-catenin signaling pathway via decreasing the expression of β-catenin. |
| Databáze: | OpenAIRE |
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