Genome screen for platelet monoamine oxidase (MAO) activity

Autor: William Wu, Howard J. Edenberg, Tatiana Foroud, Alison Goate, John P. Rice, Shantia Shears, John I. Nurnberger, Nancy L. Saccone, Ting-Kai Li, Nan Rochberg, Theodore Reich
Rok vydání: 1999
Předmět:
Zdroj: American Journal of Medical Genetics. 88:517-521
ISSN: 1096-8628
0148-7299
Popis: To identify loci involved in the control of platelet monoamine oxidase B (MAO-B) activity, a genomewide linkage screen was performed using 291 markers in 148 nuclear families containing a total of 1,008 nonindependent sib-pairs. Participants were genotyped and their platelet MAO-B activity levels were measured as part of the Collaborative Study on the Genetics of Alcoholism (COGA). Sib-pair analysis using Haseman-Elston regression was carried out with two programs. Two-point analysis on all pairs with SIBPAL indicated three markers with p-values below 0.01: D6S1018 (p = 0.0004), D2S1328 (p = 0.008), and D2S408 (p = 0.003). MAPMAKER/SIBS multipoint analyses using independent pairs(N = 409) gave maximal lod scores of 2. 0 on chromosome 6 and 1.1 and 1.4 for the two regions on chromosome 2. These results are consistent with linkage, but do not provide definitive evidence. We are currently creating a denser map in these regions and have begun genotyping a second sample in COGA.
Databáze: OpenAIRE