Abstract MP11: Elevated High Sensitivity C-Reactive Protein as a Risk Marker of the Attenuated Relationship Between Serum Cholesterol and Coronary Heart Disease at Older Age - Atherosclerosis Risk in Communities Study
| Autor: | Seamus Whelton, Probal Roy, Brad Astor, Lin Zhang, Ron Hoogeveen, Christie Ballantyne, Josef Coresh |
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| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Circulation. 127 |
| ISSN: | 1524-4539 0009-7322 |
| Popis: | Introduction: The relationship between serum cholesterol and coronary heart disease (CHD) risk is attenuated at older age, making it difficult to estimate risk in this age group. Hypothesis: We hypothesized that high sensitivity C-reactive protein (hs-CRP) would identify two subgroups of older individuals (≥65 years): one in whom cholesterol is less predictive of CHD and one in whom it is equally predictive compared to younger individuals. Methods: We calculated crude incident rates per 1,000 person-years and used adjusted Cox proportional hazards models to analyze cholesterol as a predictor of CHD in 8,947 participants with no known history of CHD who were stratified by age (53-64 or 65-75 years) and hs-CRP level ( Results: Among younger participants, total serum cholesterol was significantly associated with an increased risk of CHD regardless of hs-CRP group HR 1.39 (95% CI 1.20-1.61) for hs-CRP Conclusions: Among individuals aged 65-75 years, the association of cholesterol with CHD was strong in those with a low hs-CRP and weak in those with an elevated hs-CRP. Thus, in addition to its use as a risk factor, an elevated hs-CRP could be useful for stratifying the elderly population to aid in the interpretation of serum cholesterol in the prediction of subsequent CHD risk. |
| Databáze: | OpenAIRE |
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