A comprehensive bioinformatic analysis of RanBP9 expression and its relation to prognosis in human breast cancer

Autor:	Yiling Meng, Yingxia Ying, Meichao Zhang, Suning Zhang, Yuan Yao, Dong Li
Rok vydání:	2022
Předmět:	Cancer Research Genetics skin and connective tissue diseases
Zdroj:	Epigenomics. 14:27-42
ISSN:	1750-192X 1750-1911
DOI:	10.2217/epi-2021-0464
Popis:	Aim: To explore the role of RanBP9 in breast cancer. Materials & methods: Oncomine, TIMER, GEPIA, UALCAN, c-BioPortal databases and tissue microarray analysis were used in this study. Results: The expression level of RanBP9 is elevated in breast cancer tissues, which is associated with poor prognosis in breast cancer patients. RanBP9 exhibits genetic alterations and a decreased methylation level in cancer tissues. RanBP9 may also regulate cell cycle progression and is linked to tumor purity and the infiltrating levels of immune cells. Conclusions: RanBP9 may correlate with prognosis and immune infiltration in breast cancer, laying the foundation for future studies on the potential role of RanBP9 in breast cancer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a2f52aa2ad1717b0ecb4991066b4eec3 https://doi.org/10.2217/epi-2021-0464 Zobrazit plný text záznamu