ChemInform Abstract: Substituted 2,4-Diaminoquinazolines and 2,4-Diamino-8-alkylpurines as Antagonists of the Neurokinin-2 (NK2) Receptor

Autor:	Robert T. Jacobs, Terrance G. Ulatowski, David Aharony, C. K. Buckner, Russell C. Mauger
Rok vydání:	2010
Předmět:	Purine Chemistry Stereochemistry Antagonist Nk2 receptor General Medicine Combinatorial chemistry chemistry.chemical_compound medicine.anatomical_structure medicine Potency Purine derivative Receptor Nucleus
Zdroj:	ChemInform. 27
ISSN:	0931-7597
DOI:	10.1002/chin.199614175
Popis:	Modification of the heterocyclic nucleus of a lead pyrrolopyrimidine (1) found to be active as an antagonist at the neurokinin-2 (NK2) receptor is described. Compounds based on the purine nucleus (3) were found to be particularly interesting, and were modified in the C(2), C(4) and C(8) substituents to afford compounds with high potency.
Databáze:	OpenAIRE
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