| Autor: |
Thi Tran, Yi Shen, Hieu Nguyen, Shijie Deng, Hootan Roshandel, Mason Cooper, Jose Watson, Jeffery Byers, Paula Diaconescu, Loi Do |
| Rok vydání: |
2022 |
| Popis: |
We report on the preparation of synthetically versatile N-carboxyanhydrides (NCAs) directly from amino acids and CO2 using n-propylphosphonic anhydride. Most of the NCAs were isolated with >95% purity after simple workup, avoiding the need for tedious purification procedures typically required using conventional methods. Because the reagents and conditions employed are mild, tandem reactions with moisture-sensitive NCAs were carried out to transform them into the medicinally active alkaloids tryptanthrin and phaitanthrin A in one pot. A qualitative analysis revealed that our NCA synthesis approach is more green than conventional methods, which all directly or indirectly use the highly poisonous gas phosgene. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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