Cardiac resynchronisation therapy response predicts occurrence of atrial fibrillation in non-ischaemic dilated cardiomyopathy
| Autor: | Salvatore Luca D'Ascia, A. Lombardi, R. Santulli, Gaetano Santulli, Vittoria Marino, Cristoforo D'Ascia, Massimo Chiariello |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
education.field_of_study
medicine.medical_specialty business.industry Incidence (epidemiology) medicine.medical_treatment Population Cardiomyopathy Cardiac resynchronization therapy Atrial fibrillation Dilated cardiomyopathy General Medicine medicine.disease Heart failure Internal medicine Cardiology Medicine business education Prospective cohort study |
| Zdroj: | International Journal of Clinical Practice. 65:1149-1155 |
| ISSN: | 1368-5031 |
| DOI: | 10.1111/j.1742-1241.2011.02732.x |
| Popis: | SUMMARY Aim: The aim of this study was to determine whether or not cardiac resynchronization therapy (CRT) has a favourable effect on the incidence of new-onset atrial fibrillation (AF) in a homogeneous population of patients with non-ischaemic idiopathic-dilated cardiomyopathy and severe heart failure. Methods: We designed a single-centre prospective study and enrolled 58 patients AF nao¨ve when received CRT. After 1 year of follow-up our population was subdivided into responders (72.4%) and non-responders (27.6%), so as to compare the incidence of AF after 1, 2 and 3 years of follow-up in these two groups. Results: Already after 1 year, there was a significant (p < 0.05) difference in new-onset AF in non-responder patients with respect to responders (18.2% vs. 3.3%). These data were confirmed at 2 years (33.3% vs. 12.2%) and 3 years (50.0% vs. 15.0%) follow-up. In particular, 3 years after device implantation non-responders had an increased risk to develop new-onset AF (OR = 5.67). Conclusions: This is the first study analysing long-term effects of CRT in a homogeneous population of patients with nonischaemic dilated cardiomyopathy, indicating the favourable role of this non-pharmacological therapy on the prevention of AF. What’s known Albeit several studies examined the association between cardiac resynchronization therapy and atrial fibrillation in heart failure, results are still unclear and quite conflicting. What’s new In this study we show that in patients with non-ischemic dilated cardiomyopathy a positive response to cardiac resynchronization therapy has a favorable role on the prevention of new-onset atrial fibrillation. 1 |
| Databáze: | OpenAIRE |
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