Making Reference Genomes Useful: Annotation

Autor: Miguel García-Sancho, James Lowe
Rok vydání: 2023
Zdroj: A History of Genomics across Species, Communities and Projects ISBN: 9783031061295
DOI: 10.1007/978-3-031-06130-1_6
Popis: Through examining how the reference genomes of yeast, human and pig were annotated, in this chapter we further identify how the involvement or non-involvement of particular communities in the creation of a reference genome can affect the nature of the product. We therefore continue to distinguish the qualities of separate reference genomes, which are otherwise rendered as commensurate and equivalent objects by data repositories such as RefSeq. In doing so, we present alternative historical trajectories to the narrative centred around the Human Genome Project. In particular, this chapter conveys how the relationship between pig genomicists and a key annotation group at the Sanger Institute shaped the direction of annotation at that institution. This led the Sanger Institute group to formulate a new way of conducting ‘community annotation’, an approach that had previously been performed in a limited and attenuated fashion, for example at the jamboree meetings of Celera Genomics.
Databáze: OpenAIRE