Curcumin attenuatesstaphylococcus aureus-induced acute lung injury
| Autor: | Feng Xu, Ran Diao, Jin Liu, Liyun Shi, Yanhua Kang, Xuan-ding Wang |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Pulmonary and Respiratory Medicine
Chemokine Lung biology medicine.diagnostic_test business.industry medicine.medical_treatment Intraperitoneal injection Inflammation respiratory system Lung injury respiratory tract diseases Proinflammatory cytokine chemistry.chemical_compound Bronchoalveolar lavage medicine.anatomical_structure chemistry Immunology biology.protein Curcumin Immunology and Allergy Medicine medicine.symptom business Genetics (clinical) |
| Zdroj: | The Clinical Respiratory Journal. 9:87-97 |
| ISSN: | 1752-6981 |
| Popis: | Introduction Curcumin has remarkable anti-inflammatory and antioxidant properties. However, its effects on bacterium-induced acute lung injury (ALI) are not fully understood. Objective To investigate the protective effects of curcumin on a mouse model of S. aureus-induced ALI. Methods Mice were pretreated with intraperitoneal injection of curcumin or vehicle 2 h before Staphylococcus aureus instillation. The survival rate and bacterial burden after infection were recorded. Mice were sacrificed for the analyses of severity of pneumonia, integrity of lung barrier, disorder of coagulation cascades and extent of inflammation 12 h postinfection. The production of proinflammatory cytokines and chemokines in the lung and bronchoalveolar lavage fluid was detected. Results Pretreatment with curcumin markedly attenuated S. aureus-induced pneumonia, barrier disruption, lung edema and vascular leakage. Activation of plasminogen activator inhibitor-1 and infiltration of neutrophils were reduced by curcumin, together with lower levels of proinflammatory cytokines and chemokines. Conclusion Curcumin can alleviate S. aureus-induced ALI through multiple pathways. |
| Databáze: | OpenAIRE |
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