| Autor: |
Ling-ling Fu, Ming Yan, Yi Zhang, Xin Yu, Min Shao, Martin Gosau, Reinhard E. Friedrich, Tobias Vollkommer, Ralf Smeets, Xiang-zhi Hu, Hong-chao Feng, Li-ya Xu |
| Rok vydání: |
2022 |
| DOI: |
10.21203/rs.3.rs-2045067/v1 |
| Popis: |
Background Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent malignancy worldwide, with high incidence and poor survival rates. RBP1 is highly expressed in several kinds of cancer and plays a potential prognostic factor. However, the relationship between RBP1 and HNSCC were analyzed based on The Cancer Genome Atlas (TCGA) database. Materials and Methods RBP1 expression and clinical information were obtained from the Cancer Genome Atlas (TCGA) database. Tumor tissue and adjacent normal tissue of 3 HNSCC patients were collected to analyze the RBP1 mRNA expression level by quantitative PCR. Cox regression analysis was used to evaluate the prognostic values of RBP1 and clinical data in HNSCC. A nomogram was also established to predict the impact of RBP1 on prognosis based on Cox multivariate results. The methylation level of RBP1 in HNSC and its prognosis were analyzed in UALACN and MethSurv. Finally, the potential biological functions of RBP1 were investigated using gene set enrichment analysis (GSEA) and single sample GSEA (ssGSEA). Results The mRNA expression level of RBP1 was highly expressed in HNSCC tissue. The multivariate analysis result indicated that RBP1 is an independent prognosic factor in HNSCC(P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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