A Single Quadrupole Compact Mass Spectrometer Enabling Early Stage Synthetic Optimization of Verubecestat (MK-8931)

Autor:	Xiaoyi Gong, Li Zhang, Xiaodong Bu, Yanke Xu, David A. Thaisrivongs, Daniel Zewge
Rok vydání:	2019
Předmět:	Materials science Impurity business.industry Organic Chemistry Quadrupole Verubecestat Stage (hydrology) Physical and Theoretical Chemistry Mass spectrometry Tracking (particle physics) Process engineering business
Zdroj:	Organic Process Research & Development. 23:2758-2763
ISSN:	1520-586X 1083-6160
DOI:	10.1021/acs.oprd.9b00370
Popis:	A low-cost compact mass spectrometer was effectively utilized for identifying and tracking process impurities in the early stage development of a multistep synthetic protocol used to prepare the verubecestat drug substance. Process optimizations were influenced by the type, quantity, and final fate of impurities generated during synthesis. Employing a compact mass spectrometer for impurity identification and tracking served as a guide to redesign synthetic strategies which enabled the minimization or avoidance of undesired side products.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a2a01cc72e141944147a3b726ac486db https://doi.org/10.1021/acs.oprd.9b00370 Zobrazit plný text záznamu