Immunochemical evidence in two haplotypes for at least three D region-encoded molecules, D, L, and R
| Autor: | T H Hansen, K Ozato, M R Melino, J E Coligan, T J Kindt, J J Jandinski, D H Sachs |
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| Rok vydání: | 1981 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 126:1713-1716 |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | Sequential immunoprecipitation analyses have defined a new transplantation antigen, designated R, which in addition to the 2 previously isolated D and L molecules is encoded in the D region. All 3 of these gene products are 45,000 m.w. glycoprotein, and each bears a unique combination of specificities as recognized by monoclonal and/or conventional anti-H-2 sera. Three D region products, D, L, and R, have now been isolated from soluble antigens of both the H-2d and H-2q haplotypes. The resulted reported here also indicate that the loss-mutant BALB/c-H-2dm2 fails to express both Ld and Rd antigens. Further chemical comparisons of the primary structure of R molecules with D and L molecules will now be necessary to determine whether R antigens are the products of a unique gene, as opposed to a glycosylation or conformational variant of D and/or L molecules. In either case, the discovery of 3 D region-encoded gene products in certain haplotypes raises new questions about the evolution and regulation of expression of H-2 loci. |
| Databáze: | OpenAIRE |
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