| Autor: |
K.E. Frank, M Jung, L.A. Mitscher |
| Rok vydání: |
1998 |
| Předmět: |
|
| Zdroj: |
Combinatorial Chemistry & High Throughput Screening. 1:73-87 |
| ISSN: |
1386-2073 |
| Popis: |
A simple inexpensive apparatus is described consisting of conveniently commercially available components which is suitable for the solution phase multiple parallel synthesis of 24-72 analogs of drug-like molecules. The use of the apparatus is illustrated by preparation of a retrospective library of over 100 analogs of antimicrobial fluoroquinolones prepared in 0% to quantitative yields. Each analog was prepared in up to 150 mg quantity and each was analyzed by NMR and mass spectrometric techniques to verify its purity and identity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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