Abstract 16355: Impact of Renal Dysfunction on Outcomes After Left Ventricular Assist Device Implantation: A Systematic Review and Meta-analysis

Autor:	Garly Rushler Saint Croix, Michael Fattouh, Sandrine Lebrun, Michel A. Ibrahim, Sandra V Chaparro
Rok vydání:	2020
Předmět:	medicine.medical_specialty business.industry medicine.medical_treatment medicine.disease Comorbidity Physiology (medical) Heart failure Ventricular assist device Meta-analysis Internal medicine medicine Cardiology In patient Cardiology and Cardiovascular Medicine business
Zdroj:	Circulation. 142
ISSN:	1524-4539 0009-7322
DOI:	10.1161/circ.142.suppl_3.16355
Popis:	Background: Renal dysfunction is a common comorbidity in patients with advanced heart failure who may benefit from left ventricular assist device (LVAD) therapy. The effect of preoperative renal dysfunction on clinical outcomes after LVAD implantation remains uncertain. We conducted a systematic review and meta-analysis to compare outcomes post-LVAD in patients with and without renal dysfunction. Methods: PubMed, Medline, and EMBASE databases were searched for studies comparing outcomes in patients with and without renal dysfunction who underwent LVAD implantation for advanced heart failure. The primary outcome of all-cause mortality was reported as random effects risk ratio (RR) with 95% confidence interval. Results: Our search yielded 5,229 potentially eligible studies. We included 7 studies reporting on 26,652 patients. Patients with renal dysfunction (glomerular filtration rate (GFR) 60) (n=22,019). Conclusion: Patients with renal dysfunction have increased mortality after LVAD implantation when compared to patients with normal renal function. GFR can be used to risk stratify patients and guide decision making prior to LVAD therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a293135701e5d6edc59e5119ed47bb5f https://doi.org/10.1161/circ.142.suppl_3.16355 Zobrazit plný text záznamu