Stability of the radiopharmaceutical []DMSA: Study of the ligand exchange reaction with [99Tc]EDTA

Autor:	Jl. Moreno Frigols, J. Galvez Alvarez, R. Garcia Domenech, Mc. Garcia Muñoz
Rok vydání:	1983
Předmět:	Radiation Nuclear Energy and Engineering medicine.diagnostic_test Chemistry Ligand Spectrophotometry Inorganic chemistry 99mTc-DMSA Kinetics medicine Radiology Nuclear Medicine and imaging Nuclear chemistry Catalysis
Zdroj:	The International Journal of Applied Radiation and Isotopes. 34:1505-1508
ISSN:	0020-708X
Popis:	A kinetic study was made of the ligand exchange reaction between [ 99 m Tc]EDTA and DMSA. The results of this study indicate that this exchange reaction is closely related to temperature and pH. Kinetic and thermodynamic parameters demonstrate that both complexes—[ 99 m Tc]EDTA and [ 99 m Tc]DMSA—have a similar stability. Furthermore, the existence of an acid-basic catalysis for the global exchange reaction was established, and the catalytic parameters were calculated. These data were obtained by radiochromatography and visible spectrophotometry.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a288df241834d61d3096927b21a6cb92 https://doi.org/10.1016/0020-708x(83)90284-3 Zobrazit plný text záznamu