Synthesis of new phosphate derivative of benzothiazole and its inhibiting effect on two series of human neuroblastoma cell growth

Autor:	Mahshid Nikpour Nezhati, Elham Moniri, Nasir Ahmad Rajabi, Gholam Hossein Riazi, Reihaneh Kooshkestani, Robab Ardekani, Homayon Ahmad Panahi, Mohammad Mehdi Sadughi, Natasha Rahmani Zaker
Rok vydání:	2013
Předmět:	Stereochemistry General Chemical Engineering General Chemistry Alkylation Phosphate medicine.disease Combinatorial chemistry chemistry.chemical_compound chemistry Bromoacetic acid Benzothiazole Neuroblastoma medicine Growth inhibition IC50 Derivative (chemistry)
Zdroj:	Korean Journal of Chemical Engineering. 30:675-679
ISSN:	1975-7220 0256-1115
DOI:	10.1007/s11814-012-0191-0
Popis:	The sodium salt of di ((1-hydroxy-2-benzothiazolium-1-yl) ethyliden-1,1-H-bisphosphonic acid) orthophosphate was synthesized and its toxicity and viability effects screened on two different human neuroblastoma cell lines. This novel derivative of benzothiazole provides a new compound in connection with research and therapeutic application for tumor cell growth inhibition. Benzothiazole was alkylated in reaction with bromoacetic acid and then converted to its H-bisphosphonic acid derivative in presence of H3PO3/POCl3. The procedure led to formation of two molecules of corresponding H-bisphosphonic acid which attached together via a phosphate bridge. The investigated compound exhibits activities (IC50 value) ranging from 14–23 μM (corresponding to human neuroblastoma SK-BE (2) and SK-NM-C cells).
Databáze:	OpenAIRE
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