Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Cerebrovascular Disease
| Autor: | Jennifer H. Barrett, John Bamford, Peter J. Grant, J. Andrew Davies, Andrew J. Catto, M. H. Stickland, Angela M. Carter |
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| Rok vydání: | 1996 |
| Předmět: |
Advanced and Specialized Nursing
medicine.medical_specialty biology Vascular disease business.industry Cerebral infarction Angiotensin-converting enzyme medicine.disease Gastroenterology Surgery Genotype frequency Central nervous system disease Internal medicine Genotype medicine biology.protein Neurology (clinical) Allele Cardiology and Cardiovascular Medicine business Stroke |
| Zdroj: | Stroke. 27:435-440 |
| ISSN: | 1524-4628 0039-2499 |
| DOI: | 10.1161/01.str.27.3.435 |
| Popis: | Background and Purpose There is evidence that an allelic variation in the angiotensin-converting enzyme (ACE) gene may confer an increased risk of vascular disease. The roles of the ACE insertion/deletion polymorphism and circulating ACE levels are unknown in cerebrovascular disease. Methods We studied an insertion/deletion polymorphism within intron 16 of the ACE gene by polymerase chain reaction and plasma ACE activity in 467 cases of stroke, the pathological type of which was established by cranial CT, and 231 control subjects. ACE genotype and activity were related to stroke type and mortality at 4 weeks and 3 months. Results No difference in genotype frequency was observed between all subjects with stroke and control subjects or between control subjects and subjects with cerebral infarction or cerebral hemorrhage. Plasma ACE activity was significantly lower in stroke patients at presentation (64.1 IU/L) than in control subjects (79.6 IU/L; P D alleles ( P =.02). Among survivors, plasma ACE activity showed a mean increase of 6.9 IU/L (95% confidence interval, 3.0 to 10.8) between levels at presentation and at 3 months (73.6 IU/L), the latter being similar to ACE activity in control subjects. Conclusions Low ACE activity at stroke presentation and possession of the D allele may be associated with increased risk of early death from acute cerebral infarction. |
| Databáze: | OpenAIRE |
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