Synthesis and conformational studies of 3,4-di-O-acylated furanoid sugar amino acid-containing analogs of the receptor binding inhibitor of vasoactive intestinal peptide

Autor:	B. Krishna Mohan, G. Dattatreya Sarma, M. Udaya Kiran, Tushar Kanti Chakraborty, S. Uday Kumar, Bharatam Jagadeesh
Rok vydání:	2007
Předmět:	Molecular dynamics Chemistry Hydrogen bond Stereochemistry Intramolecular force Organic Chemistry Drug Discovery Vasoactive intestinal peptide Sugar amino acid Biochemistry
Zdroj:	Tetrahedron Letters. 48:6945-6950
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2007.07.158
Popis:	Structural analysis of the di- O -caprylated Gaa-containing analog of the receptor binding inhibitors of vasoactive intestinal peptide by various NMR techniques and constrained molecular dynamics (MD) simulation studies established a well-defined β-turn structure in DMSO- d 6 with an intramolecular hydrogen bond between TyrNH → MetCO.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a280dbe822447ec8632fb75fc1e7ce12 https://doi.org/10.1016/j.tetlet.2007.07.158 Zobrazit plný text záznamu Full Text from ScienceDirect