Six critical questions for DNA repair enzymes in skincare products: a review in dialog
| Autor: | Ronald Moy, Daniel B. Yarosh, Amanda Rosenthal |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
business.industry
DNA damage Sun protection DNA repair Photoaging Actinic keratosis Sun damage Dermatology medicine.disease Bioinformatics 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Medicine Skin cancer business Photolyase |
| Zdroj: | Clinical, Cosmetic and Investigational Dermatology. 12:617-624 |
| ISSN: | 1178-7015 |
| DOI: | 10.2147/ccid.s220741 |
| Popis: | Concerns over existing sunscreen filters have reinforced the need to examine supplemental sun protection or repair of sun damage. Technology to enhance DNA repair has been available in skincare and sunscreen products for several decades, but skepticism and lack of familiarity with the supporting data remain prevalent. Here, we address six of the main questions raised by medical professionals regarding the efficacy of DNA repair enzymes in sun protection. These include the mode of delivery and mechanism of action, the effect on cellular responses and the amelioration of pre-cancers, cancers and photoaging. The conclusions are that topical DNA repair enzymes do enhance removal of DNA damage and reduce the appearance of new actinic keratoses as well as increase regression of existing lesions. Support for prevention of photoaging and skin cancer is significant but could be strengthened or disproven with additional research. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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