| Autor: |
Marilia Alves dos Reis, Ary Gadelha, André C. Felício, Marcelo Queiroz Hoexter, Ilza Rosa Batista, Pedro Braga-Neto, Mariana Calzavara, Daniel Alves Cavagnolli, Cinthia Higuchi, Melissa Furlaneto Lellis Leite, Solange Amorim Nogueira, Jairo Wagner, Mario Luiz Vieira Castiglioni, Ming Chi Shih, Rodrigo Affonseca Bressan |
| Rok vydání: |
2020 |
| Popis: |
Purpose: The presynaptic dopamine transporter (DAT) modulates the uptake of dopamine by regulating its concentration in the central nervous system. We aimed to evaluate the DAT binding potential (DAT-BP) in a sample of healthy Brazilians through [99mTc] TRODAT-1 single-photon emission computed tomography imaging. Methods: We selected 126 healthy individuals comprising 72 men and 54 women, aged 18-80 years. We conducted semi-quantitative evaluation in transaxial slices, following which we identified the regions of interest in the striatal region using the occipital lobe as a region of non-specific DAT-BP. We found a decrease in DAT-BP in healthy individuals aged over 30 years, culminating in a 42% mean reduction after 80 years. Results: There was no difference in the decrease by age group between the right (R2 linear=0.466) and left striatum (R2 linear=0.510). Women presented a higher DAT-BP than men (women: R2 linear=0.431; men: R2 linear=0.457); nonetheless, their decrease by age group was equal to that in men. Conclusion: Our study sheds light on important DAT-BP findings in healthy Brazilian subjects. Our results will facilitate understanding of brain illnesses that involve the dopamine system, such as neuropsychiatric disorders. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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