Evaluation In Vivo and In Vitro of the Antioxidant, Antinociceptive, and Anti-Inflammatory Activities of Biflavonoids From Ouratea hexasperma and O. ferruginea
| Autor: | Milene Conceição de Souza, Queli Cristina Fidelis, Edlene Ribeiro Prudêncio, Poliana de Araujo Oliveira, Mário Geraldo de Carvalho, Bruno Guimarães Marinho, Rosane Nora Castro, Cristiano Jorge Riger, Thayane Ferreira da Costa Fernandes, Dayane Magalhães Coutinho |
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| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
Antioxidant Biflavonoids biology Traditional medicine 010405 organic chemistry Chemistry medicine.drug_class medicine.medical_treatment Arthritis Plant Science General Medicine medicine.disease biology.organism_classification 01 natural sciences Anti-inflammatory In vitro 0104 chemical sciences 010404 medicinal & biomolecular chemistry Complementary and alternative medicine In vivo Drug Discovery medicine Ouratea Rheumatism |
| Zdroj: | Natural Product Communications. 14:1934578X1985680 |
| ISSN: | 1555-9475 1934-578X |
| Popis: | Ouratea species are used for the treatment of inflammation-related diseases such as rheumatism and arthritic disorders. The Ouratea genus is a rich source of flavonoids and bioflavonoids and for this reason we evaluated the effects of the biflavonoid fractions from the leaves of O. hexasperma (OHME) and O. ferruginea (OFME) in the in vivo model of complete Freund’s adjuvant (CFA)-induced arthritis and in the in vitro model of oxidative stress and cellular viability. The CFA-induced arthritis model in rats was followed by paw volume, articular incapacitation and Randall-selitto models, as well as quantification of cytokines and serum C-terminal telopeptide of type I collagen levels. OHME and OFME demonstrated antinociceptive and anti-inflammatory activities, as well as improvement in articular incapacity and reduction in levels of interleukin 1β (IL-1β), IL-6, tumor necrosis factor α, and type 1 collagen, and increased cell viability. No adverse effects were observed. The results suggest that OHME and OFME can reduce inflammation and bone resorption besides their antioxidant action. |
| Databáze: | OpenAIRE |
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