Morphological studies on the central nervous system of rats with portacaval anastomosis which were continuously infused with ammonium acetate
| Autor: | Hirotaka Chaki, Tatuo Yamada, Takeo Kikuchi, Yutaka Shimoe, Yukifumi Kokuba |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Hepatology Glial fibrillary acidic protein biology Central nervous system Portacaval anastomosis Hyperammonemia Striatum Metabolism medicine.disease chemistry.chemical_compound medicine.anatomical_structure Endocrinology chemistry Internal medicine medicine biology.protein Ammonium acetate Astrocyte |
| Zdroj: | International Hepatology Communications. 1:302-306 |
| ISSN: | 0928-4346 |
| DOI: | 10.1016/0928-4346(93)90002-w |
| Popis: | Morphological changes in the striatum of portacaval anastomosis (PCA) rats which were continuously infused with ammonium acetate for 6 days have been studied. PCA rats with the infusion of ammonium acetate showed no neurological symptoms. However, ammonia concentration in the plasma was significantly higher than that in PCA rats without the infusion of ammonium acetate. Histologically, numerous atrophic neurons have been observed in the striatum. Moreover, glial fibrillary acidic protein (GFAP)-positive astrocytes in the same area became hypertrophied and had enlarged processes in hyperammonemic PCA rats. These results suggest that long-term hyperammonemia, which did not produce any visible neurological symptoms, might induce the morphological changes in the brain of PCA rats. These changes might be related to excessive ammonia metabolism in astrocytes. |
| Databáze: | OpenAIRE |
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