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Rheumatoid arthritis (RA) is a multi-factorial, human autoimmune disease, characterised by inflammatory and proliferative synovitis that exhibits invasive and destructive features [1]. As yet, the underlying pathogenic mechanisms of RA remain poorly understood. In order to help gain a better understanding of the disease, several animal models of RA have been developed and have been widely studied. Although these models can be very instructive, no one model reflects all aspects of the human disease illustrating the complexity and heterogeneous nature of RA (Tab. 1). |
