A dual-usage near-infrared (NIR) cell membrane targeting chimeric peptide for cancer cell membrane imaging and photothermal ablation

Autor:	Qun-Ying Shi, Ping Wang, Pei-Ling Chen, Yun Liu, Tian Chen, Li-Han Liu
Rok vydání:	2020
Předmět:	chemistry.chemical_classification Materials science Mechanical Engineering Peptide Photothermal therapy Fluorescence In vitro Cell membrane medicine.anatomical_structure Membrane chemistry Mechanics of Materials In vivo Cancer cell Biophysics medicine General Materials Science
Zdroj:	Journal of Materials Science. 55:7843-7856
ISSN:	1573-4803 0022-2461
DOI:	10.1007/s10853-020-04546-1
Popis:	Due to the low background and deep tissue penetration of near-infrared light, near-infrared fluorescence (NIRF) probes have received much attention in recent years. Cell membrane targeting probes can be used in in vitro and in vivo for living cell imaging, disease diagnosis and tumor targeted therapy. However, most of the currently available cell membrane probes are blue or green emissive fluorophores, NIRF probes are relatively rare. Herein, we designed and prepared a NIRF chimeric peptide probe named C16-CARK, which could target the tumor cell membrane with longtime retention (more than 4 h). Moreover, the C16-CARK can heat and disrupt the cell membrane upon high irradiation dose, revealing its dual roles as a cell membrane imaging probe and a photothermal agent. This kind of near-infrared fluorescence probe with cell membrane targeting and retention property provides a well design paradigm for the field of cancer imaging and treatment.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a22ac160e30a6913fd7f1db64e7f6dc5 https://doi.org/10.1007/s10853-020-04546-1 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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