Fullerene C60 complexed with poly(N-vinyl-pyrrolidone) prevents the disturbance of long-term memory consolidation
| Autor: | L. B. Piotrovskii, E. V. Kondrat’eva, I. V. Shcheglov, M. A. Dumpis, I. Ya. Podol’skii |
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| Rok vydání: | 2002 |
| Předmět: |
Materials science
Long-term memory Central nervous system technology industry and agriculture Cycloheximide Condensed Matter Physics Electronic Optical and Magnetic Materials Adduct chemistry.chemical_compound medicine.anatomical_structure chemistry Microinjections medicine Biophysics Protein biosynthesis Memory consolidation Microinjection |
| Zdroj: | Physics of the Solid State. 44:578-580 |
| ISSN: | 1090-6460 1063-7834 |
| DOI: | 10.1134/1.1462714 |
| Popis: | A microinjection of C60/poly-(N-vinyl-pyrrolidone) (C60/PVP) adduct into the dorsal hippocampus is shown to prevent the disturbance of spatial memory consolidation induced by the administration of a high dose of cycloheximide, which inhibits protein synthesis in the central nervous system by more than 90%. It is supposed that microinjections of the C60/PVP adduct into the hippocampus suppress the death of its neurons, which may be one of the essential factors that prevent the disturbance of long-term memory consolidation by protein-synthesis inhibition. Other mechanisms of the fullerene action are also possible; however, they remain as yet unknown. |
| Databáze: | OpenAIRE |
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