ChemInform Abstract: Chiral Salen-Metal Complexes as Novel Catalysts for Asymmetric Phase-Transfer Alkylations

Autor:	Vadim S. Kublitski, Pavel Krasik, Viktor Maleev, Yuri N. Belokon, Michael North, Nikolai S. Ikonnikov
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Aldimine Chemistry General Medicine Alkylation Medicinal chemistry Toluene Catalysis Metal chemistry.chemical_compound Sodium hydroxide visual_art visual_art.visual_art_medium Enantiomer Alkyl
Zdroj:	ChemInform. 30
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199945044
Popis:	Chiral, salen-metal complexes have been tested as catalysts for the C -alkylation of aldimine Schiff's bases of alanine esters with alkyl bromides under phase-transfer conditions (solid sodium hydroxide, toluene, ambient temperature, 1–10% of the catalyst). The best catalyst, which was derived from a Cu(II) complex of (1 R ,2 R or 1 S ,2 S )-[ N,N′ -bis(2′-hydroxybenzylidene)]-1,2-diaminocyclohexane, gave α-methyl-α-amino acids with enantiomeric excesses of 70–96%.
Databáze:	OpenAIRE
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