A biomimetic approach for enhancing adhesion and osteogenic differentiation of adipose-derived stem cells on poly(butylene succinate) composites with bioactive ceramics and glasses
| Autor: | Evangelia K. Siska, Aldo R. Boccaccini, Martha Kaloyianni, Eleftheria Diamanti, Michael A. Karakassides, Ioanna Koumentakou, Maria Nerantzaki, Iro Koliakou, Dimitrios N. Bikiaris |
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| Rok vydání: | 2017 |
| Předmět: |
Bone growth
Materials science Nanocomposite Polymers and Plastics Simulated body fluid Organic Chemistry General Physics and Astronomy Biomaterial 02 engineering and technology Adhesion 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Apatite 0104 chemical sciences Polybutylene succinate visual_art Materials Chemistry visual_art.visual_art_medium In situ polymerization Composite material 0210 nano-technology |
| Zdroj: | European Polymer Journal. 87:159-173 |
| ISSN: | 0014-3057 |
| Popis: | The great potential application of poly(butylene succinate) (PBSu) as a novel biomaterial has not yet been realized, mainly owing to its insufficient bioactivity and low mechanical properties, which compromise the in vivo efficacy. Our strategy is based on the hypothesis that the incorporation of bioactive ceramics with similar microstructure to native bone structure into PBSu improves its bioactivity and affects new bone growth enhancing bone formation. Bioactive CaO–MgO–SiO 2 –Na 2 O–P 2 O 5 –CaF 2 glass microparticles and fibrous hydroxyapatite nanoparticles were successfully synthesized and the resulting powders were characterized using different techniques. Afterwards, PBSu nanocomposites containing 2.5 wt% of micro-Bioglass (mBG), nano-hydroxyapatite (nHA) or mBG-nHA were prepared via in situ polymerization and were studied thoroughly in terms of their physicochemical and biological properties. We show here that our strategy was effective in accelerating the in vitro biodegradability of PBSu, in enhancing apatite formation in contact with simulated body fluid (SBF), while inducing cytocompatibility and osteogenic differentiation of rat Adipose Stem Cells (rASCs). |
| Databáze: | OpenAIRE |
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