Copper-Catalyzed Cyclization of N-Propargyl Ynamides with Borane Adducts through B–H Bond Insertion

Autor:	Tong-Yi Zhai, Xiao Li, Chong-Yang Shi, Guang-Yu Zhu, Xin-Qi Zhu, Long-Wu Ye
Rok vydání:	2021
Předmět:	Hydrogen bond Organic Chemistry Substrate (chemistry) Borane Biochemistry Medicinal chemistry Adduct chemistry.chemical_compound chemistry Functional group Copper catalyzed Physical and Theoretical Chemistry Vinyl cation N-propargyl
Zdroj:	Organic Letters. 23:8067-8071
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.1c03092
Popis:	An efficient copper-catalyzed cyclization of N-propargyl ynamides with borane adducts through B-H bond insertion has been developed. A series of valuable organoboron compounds are constructed in generally good yields with a wide substrate scope and good functional group tolerance under mild reaction conditions. Importantly, this protocol via vinyl cation intermediates constitutes a novel way of B-H bond insertion.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a21033ae19faca016bfcce803c5ec063 https://doi.org/10.1021/acs.orglett.1c03092 Zobrazit plný text záznamu