FN-C1q and C1 INH Clr-Cls complexes as indicators of complement activation in patients with chronic lymphocytic leukaemia
| Autor: | Marina V. Merkulova, Gennadi A. Ermolin, Aranka Panya, Ludmilla V. Kurmanova, George Füst, Márta Kókai, Evgeni E. Efremov, Tünde Hidvégi, Michail M. Dikov, Galina V. Vnashenkova |
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| Rok vydání: | 1989 |
| Předmět: |
biology
business.industry Chronic lymphocytic leukemia Immunology medicine.disease Complement system Classical complement pathway Leukemia Membrane glycoproteins immune system diseases hemic and lymphatic diseases biology.protein Immunology and Allergy Medicine business Receptor Complement C1q Complement C1s |
| Zdroj: | Immunology Letters. 22:1-6 |
| ISSN: | 0165-2478 |
| DOI: | 10.1016/0165-2478(89)90133-8 |
| Popis: | We have previously found low levels of C1 and C4 INH in the sera of chronic lymphocytic leukaemia (CLL) patients. Hypocomplementaemia was supposed to be the consequence of a permanent activation of the classical pathway. We have compared the levels of C1 INH-C1rC1s and C1q-FN complexes in the sera of 95 CLL patients and 100 healthy controls, because these complexes are known to be formed in the early stage of classical pathway activation. A significant increase in the level of both types of complexes was found in sera of CLL patients as compared to the controls. These findings support the assumption that the classical complement pathway is activated in the patients with CLL. |
| Databáze: | OpenAIRE |
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